Monday, July 25, 2011

Drug Classes: Thiazolidinediones (TZDs)

Used to treat: Diabetes Mellitus II

Mechanism of Action: Decreases insulin resistance at receptor sites.

Contraindications: Liver disease, moderate to sever CHF, Increases risk of limb fractures in women, may decrease effectiveness of oral contraceptives


Pregnancy Category: C - Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks

Common Medications (Brand -- Generic)
  • Actos - Pioglitazone
    • Tablets: 15mg, 30mg, 45mg
  • Avandia - Rosiglitazone
    • Tablets: 2mg, 4mg, 8mg

Common Side Effects
  • None Common
Rare, but Potentially Deadly Side Effects
  • CHF (Rosiglitazone)
  • Lactic Acidosis (Rosiglitazone)
Combination Drugs Containing:
  • Actosplus Met - Pioglitazone/ Metformin (Biguanide)
  • Duedact - Pioglitazone/ Glimepiride (Sulfonylurea)
  • Avandamet - Rosiglitazone/ Metformin (Biguanide)
  • Avandaryl - Rosiglitazone/ Glimepiride (Sulfonylurea)
Miscellaneous:
  • Usually end in -glitazone
  • Rosiglitazone is restricted to special cases due to increased risk of cardiovascular side effects


I'm sorry that the posts have been, well.. not here lately. My brother came up to visit and then announced a surprise wedding things are kind of all over the place right now. Just bear with me.

No comments:

Post a Comment